This page provides general information and does not replace an individual medical consultation. Indication, product, technique and treatment plan are decided only after assessment; not every treatment is suitable for every person.
For a comparison with other approaches to skin quality, read the introductory guide.
What it is
Polynucleotide products contain purified DNA fragments, commonly derived from fish sources. They are proposed for tissue quality, including thin or delicate areas, but formulations are not interchangeable.
What is assessed
The consultation assesses skin thickness, hydration, elasticity and the anatomical area. Evidence is developing, but available studies remain limited in size and quality.
How treatment is carried out
Skin thickness, hydration, elasticity, allergy history and the anatomical area are assessed. The doctor explains the product origin, composition and available evidence before microinjection.
Limits and alternatives
Evidence is developing but remains limited by small studies and differing protocols. Results are not universal and the treatment does not replace volume restoration or surgery.
What the literature says
A recent systematic review found encouraging results and generally good tolerability, but the available studies were small and evidence quality ranged from low to moderate.
Risks and unwanted effects
Redness, swelling, bruising and small raised injection points may occur. Allergy and inflammatory reactions are possible; product origin and composition should be discussed during the consultation.
Contraindications and medical assessment
Pregnancy, breastfeeding, active infection and allergy to product components or source material require caution or exclusion. Medical history is reviewed individually.
Aftercare and follow-up
Small raised points, redness, swelling and bruising may occur. Unexpected or persistent inflammatory symptoms should be reported.
Frequently asked questions
Are polynucleotides the same as filler?
No. They are proposed for tissue quality and are not intended to create structural volume in the same way as filler.
Sources
- Lampridou S et al. The effectiveness of polynucleotides in esthetic medicine: a systematic review. J Cosmet Dermatol, 2025 (opens in a new tab)
- Polydeoxyribonucleotide: a promising biological platform to accelerate impaired skin wound healing. Pharmaceuticals (Basel), 2021 (opens in a new tab)
Publications are cited for information and do not replace individual medical assessment.